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Lexicon: L
Leishmania and frequency therapy
Definition:
Leishmania is a genus of unicellular parasitic protozoa that cause the disease leishmaniasis. These parasites are transmitted to humans and animals through the bite of infected sandflies.
species:
There are several species of Leishmania that cause different forms of leishmaniasis, including
- Leishmania donovani: Causes visceral leishmaniasis (kala-azar), the most severe form of the disease.
- Leishmania major, Leishmania tropica: Causes cutaneous leishmaniasis, which causes skin ulcers.
- Leishmania braziliensis: Causes mucocutaneous leishmaniasis, which causes skin and mucous membrane lesions.
transmission:
- Leishmania parasites are transmitted by the bite of infected female sand flies of the genus Phlebotomus (Old World) or Lutzomyia (New World).
- The parasites develop in the mosquito's gut and are transmitted to the host during bloodsucking.
Diseases:
- Visceral leishmaniasis (kala-azar): Affects internal organs such as the liver, spleen and bone marrow. Symptoms include fever, weight loss, anaemia and enlarged organs.
- Cutaneous leishmaniasis: Causes skin ulcers that develop at the site of the bite.
- Mucocutaneous leishmaniasis: Leads to destructive lesions on the skin, mouth and nose.
Diagnosis:
- Microscopy: Detection of Leishmania parasites in tissue samples or skin ulcers.
- Serological tests: Detection of antibodies against Leishmania.
- PCR tests: Molecular methods for the detection of Leishmania DNA.
treatment:
- Antimony preparations: Traditional treatment agents, such as sodium stibogluconate.
- Amphotericin B: An antifungal drug that is also effective against leishmaniasis.
- -Miltefosine: An oral medication used against various forms of leishmaniasis.
Prevention:
- Protection against sandfly bites using insect repellent, mosquito nets and protective clothing.
- Control of sandfly populations and their habitats.
- Early detection and treatment of infections to prevent the spread.
Worth knowing:
- Leishmaniasis is common in tropical and subtropical regions, including parts of Asia, Africa, the Middle East and South America.
- The disease affects millions of people worldwide and is a significant cause of morbidity and mortality in affected areas.
Research:
Research is focussed on developing new drugs and vaccines, improving diagnostic methods and understanding the immune response to Leishmania infections.