Pseudomonas aeruginosa and frequency therapy

Definition:

Pseudomonas aeruginosa is a Gram-negative, rod-shaped found in many environments, including soil, water and human habitats. It is known for its ability to cause infections in humans, particularly in immunocompromised individuals, and is a common pathogen of nosocomial (hospital-acquired) infections.

Characteristics:

Versatility:
Pseudomonas aeruginosa can survive in a variety of environments and is resistant to many disinfectants.
Biofilm formation:
It can form biofilms on surfaces that protect it from antibiotics and the immune system.
Antibiotic resistance:
The bacterium shows a high natural resistance to many antibiotics and can quickly develop additional resistances.

Infections:

Pseudomonas aeruginosa can cause a variety of infections, including:

Respiratory tract infections:
Especially in patients with cystic fibrosis or chronic obstructive pulmonary disease (COPD).
Urinary tract infections:
Common in patients with indwelling catheters.
Wound infections:
Particularly in burns or surgical wounds.
Bacteraemia:
A serious infection that can lead to sepsis.
Skin infections:
Such as "whirlpool dermatitis", a skin infection following contact with contaminated water.

Diagnosis:

Diagnosis is made by microbiological cultures of samples from infected areas, such as sputum, urine or wound swabs. Pseudomonas aeruginosa can be identified by its characteristic green-blue pigmentation and sweet odour.

Treatment:

Antibiotics:
Treatment often requires a combination of antibiotics, as the bacterium is resistant to many single agents. Commonly used antibiotics are piperacillin-tazobactam, ceftazidime, ciprofloxacin and aminoglycosides.
Adaptation of therapy:
Based on antibiograms to determine the most effective antibiotics.

Prevention:

Hygiene measures:
Strict adherence to hygiene standards in hospitals to prevent nosocomial infections.
Disinfection:
Regular cleaning and disinfection of medical equipment and surfaces.
Surveillance:
Infection control programmes to monitor and control outbreaks.

Need to know:

Pseudomonas aeruginosa is an opportunistic pathogen that causes infections, especially in people with weakened immune systems.
It is known for its ability to survive in moist environments, making it a common problem in hospitals.

Research:

Research is focused on developing new antibiotics and treatment strategies, overcoming antibiotic resistance and understanding the mechanisms that make Pseudomonas aeruginosa so adaptable and resilient.